GBendriss'Lab @WCMQ
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TEDxDohaInstitute - Celebrating our Diversity.
Will cleanliness kill us? TEDxDohaInstituteمؤتمر التنوع يثرينا - هل ستقتلنا النظافة A public talk which contributed to raise awareness among the community on the benefits of gut microbes. |
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Austim Connect - June 10th, 2023
St Regis Marsa Arabia, Doha, Qatar. What's bugging in the Gut? A public talk which contributed to raise awareness among the community on the benefits of gut microbes and summarized results of my clinical study in Qatar. |
Research questions:
- Exploring the Gut Microbiome in Neurodevelopmental Disorders (NDD) and Gastrointestinal Diseases (GID) and how variables from lifestyle can modulate the composition.
- Optimizing a method of producing a home-made probiotic yogurt that complies with the WHO/FAO recommendations.
- Develop and test a probiotic product that could be used in Microbial Reprogramming in Autism and other pathologies with dysbiosis.
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"Role of the Gut Microbiota in Autism Spectrum Disorders and Inflammatory Bowel Diseases" is a clinical study performed in Qatar under QNRF grant obtained in 2017. The aim was to: 1/ Publish state-of-the-art literature reviews on the role of human gut microbiota in Autism spectrum disorders (ASD) and Inflammatory bowel diseases (IBD); 2/ Evaluate and raise awareness of healthcare profesionals, scientists and families in Qatar on the role of microbiota in diseases. In addition, we’ll evaluate readiness of the scientific community to the establishment of eventual clinical trials involving lifetstyle changes and fecal transplants; 3/ Produce preliminary data from locally collected stool samples, which will be compared to data produced internationally from other patients. Eventually, this will help us argue for possible lifetsyle-dependant microbial signatures for ASD vs IBD. For English and Arabic summary of the results, click here.
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"Characterization and Development of a Probiotic Yogurt using starters local to Qatar" is a synthetic biology project that aims at not only characterising the microbial content of local dairies, but also to develop a protocol that improves those probiotic characteristics.
Recently, Qatar has started to produce its own milk, its own yogurts and desserts. Only few of them specify the microbes that constitute them. This study tested several combination of starter, temperature, incubation time, milk organic or not, in order to draft with a technique to produce improved versions of these yogurts at home, with higher probiotic content and better resistance to acidity.
The aims of this study were:
Recently, Qatar has started to produce its own milk, its own yogurts and desserts. Only few of them specify the microbes that constitute them. This study tested several combination of starter, temperature, incubation time, milk organic or not, in order to draft with a technique to produce improved versions of these yogurts at home, with higher probiotic content and better resistance to acidity.
The aims of this study were:
- Characterize local yogurts and compare their probiotic content, abundance, resistance to acidity, antimicrobial property to Activia and Yeo brands.
- Optimize a method to improve probiotic diversity, abundance and resistance to acidity of local yogurts. Optimization will include time of incubation, temperature, local starter, milk type, pre-biotic additives.
- Develop a diverse probiotic formula based on previous studies to produce a probiotic drink or yogurt to be tested in vivo.
Upgrading gut diversity with a home-made probiotic: an animal study. The WHO/FAO states specific requirements for a product to be labelled as " containing probiotic". This claim requires a set of evidence and testing including a minimum number of live microorganisms resisting to acidity, and evident benefits for health. This study is looking into the effect of a home-made probiotic on rats.
Microbial Reprogramming in Obsessive-Compulsive Disorders: A Review of Gut-Brain Communication and Emerging Evidence.
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TEAMS
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Role of the Gut Microbiota in ASD and IBD
Principal Investigator: Ghizlane Bendriss, PhD Co-investigator: Noha Yousri, PhD Mentor: Dalia Zakaria, PhD Alumni: Ibrahim Laswi, Dana Al Ali, Ameena Shafiq, Mohammad Salameh, Zain Burney, Krishnadev Pillai, Nada Mhaimeed. |
Characterization and Development of a Probiotic Yogurt using starters local to Qatar
Principal Investigator: Ghizlane Bendriss, PhD
Researchers: Sama Ayoub, Noor AlNaimi, Shahad Ibrahim, Jane Manyama, Maha Al-Marri, Al Jazi Al Naimi, Alyaa ALtamimi, Abdulaziz Alansari, Christina Esteban1, Christine Gaskell.
Principal Investigator: Ghizlane Bendriss, PhD
Researchers: Sama Ayoub, Noor AlNaimi, Shahad Ibrahim, Jane Manyama, Maha Al-Marri, Al Jazi Al Naimi, Alyaa ALtamimi, Abdulaziz Alansari, Christina Esteban1, Christine Gaskell.
Selected Publications
- Ayoub, S., AlNaimi, N. ., Ibrahim, S., Manyama, J., Al-Marri, M., Al Naimi, A. J., Altamimi, A., Al Ansari, A., Esteban, C., Gaskell, C., McVeigh, C., Sebah, M., & Bendriss, G. (2023). Enhancement of Probiotic Yogurts’ Characteristics using a 24-hour fermentation process. Journal of Student Research, 11(3). https://doi.org/10.47611/jsr.v11i3.1746. 3March 2023
- Salameh M, Burney Z, Mhaimeed N, Laswi I, Yousri NA, Bendriss G, Zakaria D. The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis. Scand J Immunol [Internet]. 2020 Mar [cited 2020 Jul 7];91(3):e12855. Available from: https://doi.org/10.1111/sji.12855
- Abdellatif B, McVeigh C, Bendriss G, Chaari A. The promising role of probiotics in managing the altered gut in autism spectrum disorders. Int J Mol Sci [Internet]. 2020 Jun 10 [cited 2020 Jul 7];21(11):4159. Available from: https://doi.org/10.3390/ijms21114159
- Al Theyab, A., Almutairi, T., Al-Suwaidi, A. M., Bendriss, G., McVeigh, C., & Chaari, A. (2020). Epigenetic effects of gut metabolites: Exploring the path of dietary prevention of type 1 diabetes. Frontiers in Nutrition, 7, 563605. https:// doi.org/10.3389/fnut.2020.563605
- Al-Ali, D., Ahmed, A., Shafiq, A., McVeigh, C., Chaari, A., Zakaria, D., & Bendriss, G. (2021). Fecal microbiota transplants: A review of emerging clinical data on applications, efficacy, and risks (2015 2020). Qatar Medical Journal, 2021(1), Article 5. https://doi.org/10.5339/ QMJ.2021.5
- Bendriss, G., Al-Ali, D., Shafiq, A., Laswi, I., Mhaimeed, N., Salameh, M., Burney, Z., Pillai, K., Chaari, A., Zakaria, D., & Yousri, N. A. (2020). Targeting the gut microbiome: A brief report on the awareness, practice, and readiness to engage in clinical interventions in Qatar. Qatar Medical Journal, 2020(3), Article 47. https://doi.org/10.5339/qmj.2020.47
- A comparative pilot study of bacterial and fungal dysbiosis in neurodevelopmental disorders and gastrointestinal disorders: Commonalities, specificities and correlations with lifestyle. Microorganisms, 9(4), 741. https://doi. org/10.3390/microorganisms9040741